Introducing
microRNA Pairwise Expression Profiling
Performance Matters
Demonstrated Highest PPV and NPV*1
Negative/Moderate Thresholds
Positive
Threshold
Negative
Samples
Positive
Samples
98%
Sensitivity
Negative/Moderate Thresholds
98%
Specificity
Positive Threshold
99%
NPV
Negative Samples
96%
PPV
Positive Samples
Study Design1,3
The validation cohort consisted of samples from a previously reported fully blinded, multi-center, retrospective study in which combination testing with ThyGeNEXT® + ThyraMIR® was performed on archived FNA cytology slides from non‐consecutive subjects with indeterminate cytology. An H&E stained tissue section from the corresponding surgically resected nodule was submitted and reviewed by two independent pathologists, blinded to the molecular test results, to establish unanimous consensus diagnosis. Pairwise re-analysis of the Ct (Cycle threshold) values of the same microRNAs yielded unique microRNA expression profiles that are now reported as ThyraMIR®v2.
Flexibility Matters
Interpace Diagnostics is the only company that offers:
Thyroid Mutation Panel + microRNA Risk Classifier
Testing of fresh FNA samples or direct smears/ThinPrep® slides with a high-quality image capture
No special shipping or refrigeration requirements
Patient management decisions are based on the independent medical judgment of the physician and molecular test results should be taken into consideration in conjunction with all relevant imaging, clinical findings, patient and family history, as well as patient preference.
References
1. Finkelstein SD, Sistrunk JW, Malchoff CD, et al. A retrospective evaluation of the diagnostic performance of an interdependent pairwise microRNA expression analysis with a mutation panel in indeterminate thyroid nodules [published online ahead of print, August 9, 2022]. Thyroid. doi:10.1089/thy.2022.0124. 2. Banizs AB, Silverman JF. Diagn Cytopathol. 2019;47(4):268-274. 3. Lupo MA, et al. Diagn Cytopathol. 2020;1–11. https://doi.org/10.1002/dc.24564.
