Diagnostic Molecular Profiling Differentiating Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) from Closely Related Entities

ATA 2017, Victoria, BC, Canada
  • Follicular patterned thyroid neoplasms with papillary carcinoma nuclear features with or without invasion are increasingly recognized as a diverse group of neoplastic processes
  • While sharing similar microscopic features, the biological behavior of these entities appears to be distinct from that of usual type papillary thyroid carcinoma (uPTC)
  • Two-stage molecular analysis (mutation panel, microRNA classifier) was applied to cohorts of closely related lesions and known positive (uPTC) & negative (benign) nodules in search of discriminating diagnostic markers

Patient management decisions are based on the independent medical judgment of the physician and molecular test results should be taken into consideration in conjunction with all relevant imaging, clinical findings, patient and family history, as well as patient preference.

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