Diagnostic Molecular Profiling Differentiating Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) from Closely Related Entities

  • Follicular patterned thyroid neoplasms with papillary carcinoma nuclear features with or without invasion are increasingly recognized as a diverse group of neoplastic processes.
  • While sharing similar microscopic features, the biological behavior of these entities appears to be distinct from that of usual type papillary thyroid carcinoma (uPTC).
  • Two stage molecular analysis (mutation panel, microRNA classifier) was applied to cohorts of closely related lesions and known positive (uPTC) & negative (benign) nodules in search of discriminating diagnostic markers. 

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