For the risk stratification of indeterminate thyroid nodules

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The following independent study explores the biological functions of microRNAs—their role as the master regulators of gene expression and their relevance to thyroid cancer biology and processes. While this study includes microRNA assessed by the ThyraMIR®v2 assay, it should not be interpreted as a validation study for ThyraMIRv2 or the ThyGeNEXT® + ThyraMIRv2 combination testing platform.

  • microRNA

Ramirez-Moya J, et al. Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness. Oncogene. 2019;38(27):5486-5499. doi: 10.1038/s41388-019-0804-8.

This study identified miR-146b as the most overexpressed microRNA in papillary thyroid carcinoma (PTC), directly targeting DICER1, an RNAse III-type enzyme involved in microRNA processing. By targeting DICER1, miR-146b inhibits its expression, playing a critical role in thyroid tumor progression.

The findings demonstrated that major upregulated microRNAs in thyroid cancer, including miR-146b, promote cell proliferation, migration, and invasion by targeting DICER1. Researchers linked miR-146b to aggressive clinicopathological features and poor clinical outcomes, functioning as a prognostic factor for PTC.

The data confirm DICER1’s role as a tumor suppressor and highlights how miR-146b contributes to its downregulation, leading to increased malignancy. The findings provide insight into how DICER1 and microRNA expression patterns can provide valuable prognostic information related to thyroid cancer.

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Patient management decisions are based on the independent medical judgment of the physician and molecular test results should be taken into consideration in conjunction with all relevant imaging, clinical findings, patient and family history, as well as patient preference.

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  • microRNA

Ramirez-Moya J, et al. Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness. Oncogene. 2019;38(27):5486-5499. doi: 10.1038/s41388-019-0804-8.

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View Paper

Patient management decisions are based on the independent medical judgment of the physician and molecular test results should be taken into consideration in conjunction with all relevant imaging, clinical findings, patient and family history, as well as patient preference.