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MicroRNA Expression Profiling Differentiated Parathyroid Lesions

ASCP 2017 Chicago, IL

Thyroid nodules frequently undergo fine needle aspiration (FNA) to discriminate between benign versus malignant disease. Parathyroid processes in the form of hyperplasia (PH), adenoma (PA), and carcinoma (PC) can mimic thyroid nodular disease cytologically leading to indeterminate diagnosis. Molecular analysis, based on mutational analysis and/or RNA expression profiling, designed for thyroid neoplasia is often used as an ancillary tool. We sought discriminating features in thyroid molecular testing that would identify parathyroid tissue and indicate specific parathyroid disease states.

Patient management decisions are based on the independent medical judgment of the physician and molecular test results should be taken into consideration in conjunction with all relevant imaging, clinical findings, patient and family history, as well as patient preference.