Follicular patterned thyroid neoplasms with papillary carcinoma nuclear features, with or without invasion, are increasingly recognized as a diverse group of neoplastic processes.
- NIFTP is unlikely to undergo metastatic spread and thus treated by lobectomy
- iEFVPTC, reflecting neoplastic progression with microscopic evidence of capsular invasion, is regarded as malignant
Mutational findings between these two closely related states does not discriminate between them.
Using well-characterized cohorts of these two entities, we show in microdissected tissue that microRNA (miRNA) profiling can effectively differentiate these entities.