MicroRNA (miRNA) Profiling Differentiates Noninvasive Follicular Thyroid Neoplasm with Papillarylike Nuclear Features (NIFTP) from Invasive Encapsulated Follicular Variant of PTC (iEFVPTC)

Follicular patterned thyroid neoplasms with papillary carcinoma nuclear features, with or without invasion, are increasingly recognized as a diverse group of neoplastic processes.
NIFTP is unlikely to undergo metastatic spread and thus treated by lobectomy.
However, iEFVPTC, reflecting neoplastic progression with microscopic evidence of capsular invasion, is regarded as malignant.
Mutational findings between these two closely related states does not discriminate between them.
Using well characterized cohorts of these two entities, we show in microdissected tissue that microRNA (miRNA) profiling can effectively differentiate these entities.

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