MicroRNA Profiling Complements Microscopic/Mutational Analysis by Defining Alternative Pathways of Carcinogenesis

USCAP 2017, San Antonio, TX

Thyroid follicular cell neoplasia is biologically heterogeneous, ranging from benign to indolent malignancy to high-grade cancer. Mutation genotyping is effective at predicting tumor aggressiveness. Aggressive disease can be seen in a significant minority of cases where common driver mutations are undetected. We performed a correlative analysis of microRNA profiling with specific patterns of thyroid follicular cell nodules using a large clinical case database (n=5210) seeking discriminating information.

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