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MicroRNA Profiling Discriminates Nodular Hyperplasia Versus Follicular Adenoma

ATA 2018 Washington DC

A variety of benign entities produce thyroid nodular disease, the two most common being nodular hyperplasia (NH) and follicular adenoma (FA).

NH is non-neoplastic, not requiring surgical excision unless symptomatic.

FA, considered neoplastic, can justify local resection when viewed as a precursor for progression to cancer.

Current molecular testing based solely on mutational analysis or RNA classifier does not differentiate between these or other benign states limiting surgery decision-making.

We show that microRNA (miRNA) profiling can discriminate NH from FA with high accuracy for more informed molecular assessment of cytologically indeterminate nodular disease.

Patient management decisions are based on the independent medical judgment of the physician and molecular test results should be taken into consideration in conjunction with all relevant imaging, clinical findings, patient and family history, as well as patient preference.