microRNA Expression Helps Drive
Cancer Initiation and Progression1
microRNAs (miRNA) are Master Regulators of Protein Synthesis and Cellular Function
- miRNAs are an important class of small RNAs that target and bind to messenger RNA (mRNA), regulating gene expression (protein synthesis)2
- More than 50% of human mRNAs may be influenced by miRNA-mediated regulation and are associated with several human cancers1
- By modulating protein synthesis, miRNAs regulate cellular processes such as survival, proliferation, migration, and death3
miRNAs Assessed by ThyraMIR® Can Help Rule in all Types of Thyroid Cancers4,5
| FTC | PTC | PDTC | ATC | MTC | |
|---|---|---|---|---|---|
| Upregulated | miR-222-3p | miR-222-3p | miR-222-3p | miR-222-3p | miR-375 |
| miR-146b-5p | miR-146b-5p | miR-146b-5p | miR-146b | ||
| miR-31-5p | miR-551b | ||||
| Downregulated | MiR-139-5p | miR-204-5p | miR-204-5p | miR-138-1-3p | |
| miR-155-5p | miR-29b-1-5p | ||||
| miR-155-5p |
ThyraMIR Assesses miRNA Expression in Indeterminate Thyroid Nodules to Help Further Inform Risk of Malignancy
References
1. Boufraqech M, Klubo-Gwiezdzinska J, Kebebew E. MicroRNAs in the thyroid. Best Pract Res Clin Endocrinol Metab. 2016;30(5):603-619. 2. Fuziwara CS, Kimura ET. MicroRNAs in thyroid development, function and tumorigenesis. Mol Cell Endocrinol. 2017;456:44-50. 3. Hu Y, Wang H, Chen E, et al. Candidate microRNAs as biomarkers of thyroid carcinoma: a systematic review, meta-analysis, and experimental validation. Cancer Med. 2016;5(9):2602-2614. 4. Visone R, Pallante P, Vecchione A, et al. Specific microRNAs are downregulated in human thyroid anaplastic carcinomas. Oncogene. 2007;26(54):7590-7595. 5. Nikiforova, MN, Tseng GC, Steward D, et al. MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility. J Clin Endocrinol Metab. 2008;93(5):1600-1608. 6. Banizs AB, Silverman JF. The utility of combined mutation analysis and microRNA classification in reclassifying cancer risk of cytologically indeterminate thyroid nodules. Diagn Cytopathol. 2019;47(4):268-274.
