- Medullary thyroid carcinoma (MTC) is a rare neuroendocrine cancer originating from parafollicular C-cells that produce calcitonin
- MTC accounts for 5%-10% of all thyroid carcinomas (Note: Prevalence was also found to be lower, with a range of 2%-5%)
- Age and stage of disease at the time of diagnosis are the main prognostic indicators
- Diagnosis of MTC can be challenging in thyroid fine needle aspiration (FNA) cytology specimens
- Cytologic appearance of MTC can overlap with other thyroid neoplasms, thereby preventing a definitive diagnosis
- This study was designed to identify distinguishing molecular characteristics of MTC versus other thyroid neoplasms, for use in limited specimens such as FNA biopsies
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