Performance Attributes of Microdissected Slide-Format and Dedicated Needle Aspiration Biopsy Analysis of Indeterminate Thyroid Nodules

ATA 2017 Victoria, British Columbia, Canada
  • Molecular analysis of cytologically indeterminate thyroid nodules can help predict biological aggressiveness (benign versus low-grade malignancy versus high-grade malignancy)
  • Two general testing formats are available:
    • Separate dedicated needle biopsy/rinse
    • Material from cytology/surgical pathology microscopic slides
  • We previously reported two-stage molecular testing (mutation panel and microRNA classifier) diagnostic yield and performance with needle aspirate/rinse specimens
  • Here we extend the review to the different slide formats that are available, incorporating microdissection to enrich for cells of interest

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