Show Me The Money! Institutional Experience with Molecular Testing of Thyroid Nodules

ATA 2018, Washington, DC
  • Cytology from thyroid nodule biopsy often shows atypia of undetermined significance (AUS) leading to surgery for ultimately benign histology 
  • Molecular testing, such as ThyGenX/ThyraMIR, can augment clinical decision-making in thyroid nodule management
  • ThyGenX/ThyraMIR testing identifies mutations and provides variable risk of malignancy based on genotype and miRNA expression profile
    • ThyGenX assesses common genetic alterations across 8 genes associated with papillary and follicular carcinoma
    • ThyraMIR is a miRNA gene expression classifier based on evaluation of expression of 10 short, non-coding miRNAs that regulate translation
  • This project examined ThyGenX/ThyraMIR testing of thyroid nodules in the San Antonio Military Health System (SAMHS)
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